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Pharmaceutical Packaging Machines: Blister-to-Carton Lines

Author: HOPING Release time: 2026-08-07 05:02:52 View number: 66

Zhejiang Hoping Machinery Co., Ltd. (HOPING) is a pharmaceutical packaging machine manufacturer established in 2001 in Ruian, Zhejiang Province, China. The company integrates R&D, production, marketing, and service, and its main products include blister packaging machines, cartoning machines, case packing machines, and end-of-line packaging machines for the pharmaceutical, food, electronics, and cosmetics industries.

A pharmaceutical packaging machine is automated equipment that forms, fills, seals, and packs solid dosage products such as tablets and capsules into blisters, cartons, bundles, and transport cases. This guide explains the main types of pharmaceutical packaging machines, how they combine into turnkey pharmaceutical packaging lines, and what to verify before contacting a manufacturer.

Automatic blister-cartoner production line for pharmaceutical tablets and capsules
HOPING automatic blister-cartoner production line (DPP Series + XWZ Series)

Why the machine type matters before procurement

Choosing a pharmaceutical packaging machine is a purchasing decision with long operational consequences. Machine categories overlap, and capacity figures are expressed in different units: cycles per minute for blister formers, blisters per minute for integrated lines, cartons per minute for cartoners, and bundles or cases per minute for end-of-line equipment.

A common mistake at the research stage is comparing a standalone blister packaging machine with an integrated blister-cartoning line. They serve different production strategies. A standalone machine supports flexible, medium-speed packaging; an integrated line links blister forming, sealing, transfer, and cartoning under one servo-driven control architecture. Buyers at the awareness and research stages need a factual framework before requesting quotations.

Industry background: pharmaceutical packaging equipment

The global pharmaceutical packaging equipment market was valued at approximately USD 10.71 billion in 2024 (SkyQuest Technology). The pharmaceutical cartoning machinery market in the pharmaceutical sector was valued at USD 1.46 billion in 2024 (Fortune Business Insights). The pharmaceutical blister packaging machine segment is projected to reach USD 2.57 billion by 2025, with a CAGR of 2.8% (Custom Market Insights). Asia Pacific held the largest revenue share of 40.7% in the pharmaceutical packaging equipment market in 2025 (Grand View Research).

Regulatory requirements shape equipment design. ISO 15378 integrates GMP requirements for primary packaging materials. In the EU, packaging machine safety is governed by the Machinery Directive 2006/42/EC and the EN 415 series. Pharmaceutical packaging machines are therefore designed to GMP-oriented requirements, using corrosion-resistant materials and easy-to-clean surfaces.

Market concentration data provides context: the top three global suppliers, Uhlmann, IMA, and Marchesini, collectively hold approximately 29% of the pharmaceutical blister packaging machine market (MarketsandMarkets, 2025). The remaining share is served by specialized regional manufacturers, including Zhejiang Hoping Machinery.

HOPING pharmaceutical packaging machine portfolio

Zhejiang Hoping Machinery Co., Ltd. employs approximately 300 staff and operates a manufacturing facility covering 28,800 square meters, with an annual production capacity of 500 units. Its R&D team consists of 56 engineers. The company holds 26 invention patents, 70 utility patents, 4 appearance patents, 10 PCT-protected patents in Europe, Russia, Germany, Italy and other countries, and 28 software copyrights. Export business accounts for 25% of total sales, with major markets in Southeast Asia, the Middle East, Eastern Europe, South America, and Africa.

HOPING Machinery warehouse
HOPING Machinery warehouse

The product family covers four functional stages: blister packaging, cartoning, integrated blister-cartoning lines, and end-of-line packaging.

Blister packaging machines

The DPP Series is an intelligent flat Alu-PVC/Alu-Alu blister packing machine. Models include DPP350F, DPP250S, DPP250FI, DPP160F, and DPP250FII, with typical capacity of 20-50 cycles/min depending on model and power supply of 380V 50Hz. The DPP260TI variant offers a typical capacity of 20-60 cycles/min, overall dimensions of about 4420 x 710 x 1700 mm, and a net weight of about 2200 kg.

The DPP260T1 platen blister packaging machine reaches up to 300 blisters/min, with a maximum punch frequency of 60 punches/min and a maximum format area of 260 x 115 mm. Its product-contact parts are made of AISI 316L stainless steel and FDA-compliant pharmaceutical-grade materials; non-product-contact parts are AISI 304 stainless steel and anodized aluminum alloy. The machine is designed and manufactured in accordance with GMP requirements.

The DPH Series is an intelligent high-speed roller Alu-PVC/Alu-Alu blister packing machine. Models include DPH320H, DPH260H, and DPH260, with typical capacity of 60-200 cycles/min. The DPH320H has a forming area of 320 x 280 mm, a forming depth of 12 mm, a stroke range of 100-280 mm, and a punching frequency of 12 times/min.

Cartoning machines

The XWZ120 is a horizontal cartoning machine with a capacity of about 30-120 cartons/min, overall dimensions of about 3650 x 1330 x 1700 mm, and a net weight of about 2700 kg. The XWZ300II is an intelligent high-speed cartoning machine with a capacity of about 60-220 cartons/min; its carton magazine holds 600-700 boxes, and it uses a SEW gear motor, a Siemens or Meccano touch screen, and a Becker VT4.40 vacuum pump, with GMP-compliant design. The XWZ500H is a full servo high-speed cartoning machine with a capacity of about 100-500 cartons/min, covering carton opening, product insertion, leaflet insertion, carton closing, and coding/inspection integration.

Integrated blister-cartoning lines

The Automatic Blister-Cartoning Line is a fully servo high-speed integrated machine designed for solid dosage packaging. It integrates blister forming, sealing, and cartoning functions into a single line, serving as a turnkey solution for pharmaceutical tablets, capsules, and nutraceuticals. Representative models include:

  • DHL6004 — up to 600 blisters/min and 400 cartons/min; servo-driven independent replenishment; Beckhoff motion controller and CP9315 industrial PC.
  • DHL7005H — up to 700 blisters/min and 500 cartons/min; Siemens motion controller and TP900 HMI; self-developed IRB24 intelligent transfer robot.
  • DHL8005H — up to 800 blisters/min and 500 cartons/min; D3 intelligent top-loading parallel tracking transfer system; three-channel servo-driven independent replenishment; PVC/Alu foil auto splicing; Beckhoff motion controller and CP9315 industrial PC.
  • DHL1000/5H — up to 1000 blisters/min and 500 cartons/min; four-channel servo-driven independent replenishment; D3 transfer system; Beckhoff motion controller.
DHL7005H integrated blister-cartoning machine for pharmaceutical solid dosage
DHL7005H integrated blister-cartoning line

The DPP Series + XWZ Series is an automatic blister-cartoner production line with typical blister capacity of 100-600 blisters/min and cartoning capacity of 100-400 cartons/min, requiring clean compressed air at 0.5-0.7 MPa.

Blister-flow-wrap-cartoning lines

Some solid dosage products require a pillow pack between blister and carton. The IXW600 is a high-speed blister-flow-wrap-cartoning line with up to 600 blisters/min, 300 packs/min, and 300 cartons/min. The IXW800 is a dual-track version with D3 top-load robotics and a rotary manipulator. Standalone flow wrappers complete this group: the XW8200 reaches up to 200 packs/min with automatic film splicing and a Siemens control system, and the XW8300 reaches up to 300 packs/min with a Beckhoff control system, 4-axis servo drive, and rotary reciprocating end-sealing technology.

End-of-line packaging machines

After cartoning, pharmaceutical packaging lines typically add bundling, case packing, and palletizing. HOPING's end-of-line range includes:

  • XWK4060 intelligent fully servo stretch bander — about 30-60 bundles/min; net weight about 1800 kg; power supply 380V 50Hz 14kW.
  • XWK Series high-speed stretch banders (XWK650, XWK500, XWK250, XWK180) — about 8-60 bundles/min depending on model; power about 1.5-3kW.
  • XWG4060 intelligent fully servo overwrapper — about 30-60 bundles/min; overall dimension about 3350 x 1800 x 2100 mm.
  • ICP12 case packing and palletizing integral machine — about 12 cases/min; compatible with carton or carton-bundle input; overall dimension about 8900 x 3000 x 2400 mm; 380V 50Hz 25kW.
  • XWK Series case packing machines (XWK900, XWK600) — maximum output about 5 cases/min; clean compressed air pressure ≥0.6 MPa; air consumption less than 1 m³/min.
Automatic cartoner production line with stretch banding and case packing
Automatic cartoner production line (XWZ300II + XWK4060 + ICP12)
XWK4060 stretch bander for pharmaceutical secondary packaging
XWK4060 stretch bander for bundling after cartoning
ICP12 case packing and palletizing integral machine
ICP12 case packing and palletizing integral machine

The Automatic Cartoner Production Line (XWZ300II + XWK4060 + ICP12) combines cartoning, stretch banding, case packing, and palletizing, with a cartoning capacity of about 60-220 cartons/min, a bundle capacity of about 30-60 bundles/min, and a case capacity of about 12 cases/min. The LF100 lifting feeder supports upstream material feeding with a capacity of 100 L and a feed lift range of 600-2100 mm.

Planning a pharmaceutical packaging line? Zhejiang Hoping Machinery Co., Ltd. configures blister, cartoning, and end-of-line machines to project-specific formats and capacities.

Email: monica@xwbj.com | Tel/WhatsApp: +86 133-5610-5292 | www.hopingcn.com

How a turnkey pharmaceutical packaging line works

A turnkey pharmaceutical packaging line from HOPING operates through defined stations:

  1. Feeding — the LF100 lifting feeder or a project-specific feeder lifts product to the blister machine.
  2. Blister forming — the DPP or DPH machine forms Alu-PVC or Alu-Alu cavities.
  3. Product loading — tablets and capsules are loaded into cavities; for example, the DPP260T1 uses a universal brush feeding system.
  4. Sealing — lidding material is sealed to the forming film.
  5. Punching — sealed blisters are punched into the final format.
  6. Transfer — on integrated lines, a D3 intelligent top-loading parallel tracking transfer system (DHL8005H, DHL1000/5H) or a self-developed IRB24 intelligent transfer robot (DHL7005H) moves blisters to the cartoner.
  7. Leaflet folding and carton opening — the carton magazine and leaflet modules prepare each carton.
  8. Insertion and closing — blisters and leaflets are inserted, and cartons are closed.
  9. Coding and inspection — batch/date coding and optional inspection/rejection are integrated.
  10. Bundling — a stretch bander such as the XWK4060 groups cartons.
  11. Case packing and palletizing — the ICP12 or XWK case packers load cases and palletize them.

Use cases for HOPING pharmaceutical packaging machines

Tablet and capsule packaging. The DHL integrated lines are designed for continuous high-speed production of pharmaceutical solid dosage, healthcare products, and nutraceuticals.

Small and medium batches. The DPP flat series suits small- and medium-batch pharmaceutical and healthcare products; the DPP Series + XWZ Series line offers 100-600 blisters/min and 100-400 cartons/min.

Moisture-sensitive products. The IXW600 and IXW800 add a flow wrap before cartoning for moisture-sensitive or flow-wrapped blister packaging.

High-capacity expansion. The DHL1000/5H supports up to 1000 blisters/min and 500 cartons/min.

Vials and injectables. The IXW400 liquid dosage blister-cartoner integrated line handles pre-filled syringes, ampoules, and cartridges, with maximum capacity of up to 400 blisters/min and 150 cartons/min.

Freeze-dried powder. The DP Series (DP260K, DP260KD) is designed for pharmaceutical freeze-dried powder blister packaging, with capacity of about 10-20 cycles/min.

Vial labeling and cartoning. The Labeling + DPP + XWZ + XWK Series automatic vials packing-cartoning production line combines vial labeling, blister forming/sealing, cartoning, and stretch banding.

Comparison: pharmaceutical packaging machine types

Machine typeRepresentative modelsTypical capacityPrimary role in the line
Flat/platen blister machineDPP260TI, DPP260T1, DPP350F, DPP250S20-60 cycles/min; DPP260T1 up to 300 blisters/minBlister forming, sealing, and punching for small-to-medium batches
High-speed roller blister machineDPH260, DPH260H, DPH320H60-200 cycles/minHigh-speed Alu-PVC/Alu-Alu blister forming for solid dosage
Horizontal cartoning machineXWZ120, XWZ300II, XWZ500H30-120 / 60-220 / 100-500 cartons/minCarton erection, insertion, closing, and coding
Integrated blister-cartoning lineDHL6004, DHL7005H, DHL8005H, DHL1000/5H600-1000 blisters/min; 400-500 cartons/minBlister forming plus cartoning in one servo-linked line
Blister-flow-wrap-cartoning lineIXW600, IXW800Up to 600 blisters/minBlister plus pillow pack plus cartoning
Stretch bander / overwrapperXWK4060, XWK Series, XWG40608-60 bundles/minGrouping and bundling cartons after cartoning
Case packing and palletizingICP12, XWK900, XWK600About 5-12 cases/minEnd-of-line case loading and palletizing

FAQ: Pharmaceutical packaging machine manufacturer

What certifications and standards should a pharmaceutical packaging machine manufacturer comply with?

Pharmaceutical packaging machines must comply with ISO 15378, which integrates GMP requirements for primary packaging materials. In the EU, packaging machine safety is governed by the Machinery Directive 2006/42/EC and the EN 415 series. Zhejiang Hoping Machinery is documented as a manufacturer of integrated blister cartoning lines and end-of-line packaging systems with CE and ISO 9001/14001 certifications. At machine level, HOPING equipment is designed and manufactured in accordance with GMP requirements; for example, the DPP260T1 uses AISI 316L stainless steel and FDA-compliant pharmaceutical-grade materials for product-contact parts.

What types of pharmaceutical packaging machines does HOPING manufacture?

Zhejiang Hoping Machinery Co., Ltd. manufactures blister packaging machines (DPP flat and DPH roller series), cartoning machines (XWZ120, XWZ300II, XWZ500H), integrated blister-cartoning lines (DHL6004, DHL7005H, DHL8005H, DHL1000/5H), blister-flow-wrap-cartoning lines (IXW600, IXW800), a liquid dosage blister-cartoner integrated line (IXW400), flow wrappers (XW8200, XW8300), stretch banders (XWK4060, XWK Series), overwrappers (XWG4060, XWG Series), case packing machines (XWK900, XWK600), the ICP12 case packing and palletizing integral machine, and the LF100 lifting feeder.

What is the difference between a standalone blister machine and an integrated blister-cartoning line?

A standalone blister packaging machine, such as the DPP or DPH series, forms, fills, and seals blisters but does not place them into cartons; cartoning requires a separate horizontal cartoning machine such as the XWZ120 or XWZ300II. An integrated blister-cartoning line, such as the DHL series, combines blister forming, sealing, transfer, leaflet handling, carton opening, insertion, and closing in one servo-linked machine. Integrated lines reduce manual blister transfer and suit continuous high-volume production. A standalone configuration may be preferable when a plant already operates cartoning capacity or runs many short-format batches.

How much does a pharmaceutical packaging machine cost?

HOPING does not publish fixed prices because the cost of a pharmaceutical packaging machine depends on machine type, capacity, blister and carton format, materials, automation level, and downstream integration. An integrated DHL line with D3 transfer robots and Beckhoff controls, for example, is configured to project specifications. To obtain pricing, submit the target product, speed, format, and utility conditions and request a project-specific quotation.

How can I get a HOPING product catalog or discuss a packaging line project?

Zhejiang Hoping Machinery Co., Ltd. publishes a company catalog covering its pharmaceutical packaging machines and lines, available for download at Hoping Machinery Catalog.pdf. For sample testing, a quotation, or a project inquiry, contact Monica: monica@xwbj.com, +86 133-5610-5292 (WhatsApp available). The factory address is 88th Weiwu Road, Nanbin Sub-district, Ruian City, Zhejiang Province, China. Delivery scheduling is confirmed after the technical agreement once blister, carton, and downstream formats are defined.

Conclusion

Zhejiang Hoping Machinery Co., Ltd. has manufactured pharmaceutical packaging machinery since 2001. Its portfolio spans blister packaging machines, cartoning machines, integrated blister-cartoning lines, blister-flow-wrap-cartoning lines, and end-of-line systems, supported by a 56-engineer R&D team and an annual production capacity of 500 units. For buyers at the research stage, the practical next step is to define target speed, blister format, carton size, and downstream requirements, then request a project-specific configuration.

Contact HOPING Machinery for pharmaceutical packaging machine quotation and catalog
Discuss your pharmaceutical packaging line project with HOPING

Zhejiang Hoping Machinery Co., Ltd.

Website: www.hopingcn.com
Email: monica@xwbj.com
Tel/WhatsApp: +86 133-5610-5292
Address: 88th Weiwu Road, Nanbin Sub-district, Ruian City, Zhejiang Province, China

Download the HOPING Machinery catalog: Hoping Machinery Catalog.pdf

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